Chien-Chang Lee

Deputy director of Center of Intelligent Healthcare, National Taiwan University Hospital
National Taiwan University Hospital

Chien-Chang Lee, MD, ScD, is a professor of emergency medicine at National Taiwan University Hospital and president of the Taiwan Society of Pediatric Emergency Medicine. As well as being an expert in medical artificial intelligence, he is also the deputy director of the Center for Intelligent Healthcare in Taiwan. He graduated from NTU and completed a residency in emergency medicine at NTU hospital. Having a passion for clinical and population research, he earned a doctorate in pharmacoepidemiology and biostatistics from Harvard University.
A modern hospital's emergency room is the hub of clinical diagnosis for patients with acute undifferentiated symptoms. Thus, new diagnostic technologies are most useful in the emergency room. Professor Lee's laboratory has extensive experience evaluating the clinical value of new laboratory tests. As a pioneer in Taiwan's EM practice, he introduced several new biomarkers of sepsis and point-of-care multiplex PCR systems. He summarizes the latest evidence on the clinical utility of new diagnostic tests constantly. Having published more than 50 systematic reviews and meta-analyses on diagnostic tests. He is an active advocate of evidence-based laboratory medicine. At NTUH, Professor Lee runs a Biomedical Data Science lab that includes 30 native students, 20 international students, and 10 international collaborators. He specialized in five research fields, including translational diagnostic medicine, big data epidemiology, computational biology, evidence-based medicine, and artificial intelligence in clinical medicine. Professor Lee made an impactful discovery regarding aortic dissections or aortic aneurysm ruptures occurring after exposure to fluoroquinolone antibiotics. A series of pharmacoepidemiology studies published by Professor Lee in prestigious journals, such as JAMA Internal Medicine and Journal of the American College of Cardiology, led the Food and Drug Administration of the United States to issue an official warning to change global antibiotic prescription guidelines. According to an FDA warning issued on December 20, 2018, fluoroquinolones should not be used in elderly patients with hypertension, peripheral vascular disease, or congenital collagen defects, such as Marfan or Ehlers-Danos syndrome, unless alternative antibiotics cannot be used. As a result of the new guideline, thousands of aortic dissections and aneurysm ruptures are expected to be prevented in the US alone.
In 2021, Stanford University selected professor Lee as one of the top 2% scientists worldwide based on his 250 scientific papers, more than 10,000 citations, and a H-index of 53.