Name /Center for Medical Devices
Address /Room 605, Jan-Shu Hall, No. 1, Sec. 4, Roosevelt Road, Taipei, 10617 Taiwan
Name /Ya-Cherng Chu
We are a research team in the Center for Medical Devices, National Taiwan University. Our team specializes in identifying molecular receptors that can be activated by ultrasound or piezoelectric stimulation. We also study the cellular machinery triggered by these receptors and the associated biological consequences for possible therapeutic applications. We are an interdisciplinary team. Our members include medical doctors, biologist and engineers. We are eager to bring our research results to the market so that many patients can benefit from our solutions.
We develop piezoelectric stimulation solutions as a therapeutic treatment for osteoarthritis patients. There are 240 million osteoarthritis patients worldwide. An effective treatment for osteoarthritis could turn into a sizable business opportunity. Our long-term goal is to repair/slowdown the cartilage damage in these patients. For the short term, we focus on relieving pain induced by osteoarthritis. Our product is an ultrasound system with a patented phase-array probe that can generate shear stress along the ultrasound propagation path. The shear stress interacts with collagen in the cartilage to create piezoelectric effects locally to stimulate the nearby chondrocytes. Without our unique probe design, the induced piezoelectric effect by regular ultrasound is almost negligible. We have published a number of articles on the biological effects of piezoelectric stimulation at the cellular level. We also obtained clear evidence in our animal study that piezoelectric stimulation reduced pain in an osteoarthritis rat model and the treatment outcomes were comparable with corticosteroid. Based on the molecular mechanism discovered in our study, we are confident piezoelectric stimulation provides a long-lasting pain relief without any side effect. We believe our solution can help a large part of the 240 million osteoarthritis patients worldwide.
Name /Ya-Cherng Chu