2020台灣生技月 Bio Taiwan 生物科技大展

2020 台灣生技月 南港展覽館

講師

TMS Co., Ltd.

Company Presentations

Thursday, July 23 Company Presentations 3–Japan

TMS Co., Ltd.

Company Info

Name /TMS Co., Ltd.

Address /1-23-3, Miyamachi, Fuchu-shi, Tokyo 183-0023 JAPAN

Website /www.tms-japan.co.jp

Presenter

Name /Takuro Wakabayashi

Title /CEO

Email /wakabayashi@tms-japan.co.jp

Telephone /(Work) +81-42-306-5078

Fax /+81-42-306-5078

Mobile /+81-70-7772-9851

Company Type

Biotechnology

About the Company

TMS, a Tokyo-based biotech company, develops SMTP family compounds for treatment of various inflammation-centric diseases. SMTPs are novel, naturally-derived small molecules. SMTP’s anti-inflammatory activity is caused by inhibition of soluble epoxide hydrolase (sEH). sEH is a part of arachidonic acid cascade, known for its association with inflammation. SMTP inhibits sEH in a novel way which led to dramatic improvement of various inflammation-associated diseases in vivo. Some SMTP compounds also have thrombolytic activity through modulation of plasminogen (dual MoA).

TMS is preparing for IPO at Tokyo Stock Exchange with Nomura as an underwriter.

Brief Description of main products or services

TMS-007, the company’s lead pipeline and a part of SMTP family, is in Phase 2a clinical trial in Japan, for acute ischemic stroke (AIS) indication. TMS has partnered with Biogen for the program since Jun, 2018. TMS-007 not only inhibits sEH and has cerebroprotective activity, but also modulates plasminogen and has thrombolytic activity, which makes the small molecule compound the ideal candidate as an AIS therapeutic agent. The largest advantage of TMS-007 over past cerebroprotective agents is it doesn’t need to be used in combination with rt-PA.

TMS-008 also belongs to SMTP and is at preclinical stage. Its targeted indications are kidney, liver, and other inflammatory diseases. TMS-008 is expected to enter into clinical stage in 2022.

Contact Person

Name /Takuro Wakabayashi

Email /wakabayashi@tms-japan.co.jp

Phone /(Work) +81-42-306-5078