Session 10 – Gene Editing & Microbiome
Date: 26 July (Friday) 14:00 – 18:00 Venue: 3F, Bldg. A, CTBC Financial Park, Ballroom B
Professor, Vincent and Stella Coates Endowed Chair
University of California, San Francisco
Dr. McManus obtained his Ph.D. studying insertional/deletional RNA editing in the laboratory of Stephen L. Hajduk at the University of Alabama in Birmingham. His postdoctoral training in the laboratory of Nobel Laureate Phillip A. Sharp at the Massachusetts Institute of Technology (MIT), focused on the study of RNA-interference and microRNA pathways in mammals. He is the Vincent and Stella Coates Endowed Chair Professor at the University of California San Francisco, in the Department of Microbiology and Immunology. He is the founder and Director of the W.M. Keck Center for Noncoding RNAs and oversees the ViraCore at UCSF. He has a long-standing interest in post-transcriptional gene regulation and the role of small RNAs in gene expression and carries almost 20 years experience working with systems biology and synthetic biology the regulation of gene expression. Over the last ten years his group has developed ultra-high-throughput screening approaches and has developed a large number of mouse gene knockout models for studying mammalian development and disease. There is a strong technology aspect to his work on uncovering mechanisms for gene regulation and roles in human disease.
Session Speech Title & Synopsis: Illuminating the Genome with CRISPR
Systematically deconvoluting molecular networks of coding and noncoding genes. Although the human genome has been sequenced, there remains a lot of mystery about its content. A major challenge across all fields in biology is the central problem of understanding genes and their roles in development and disease. This challenge that requires the use of innovative, high throughput approaches to address function. Our group develops genome-scale function-based screening platforms and other high-throughput methodologies to uncover gene function and regulatory pathways in the mammalian system. Life depends on genetically encoded networks to help make sophisticated decisions influenced by the environment. Our studies add significantly to our understanding of how cells react to their environments and will shed new insight into genomic dark matter. Importantly, we develop quantitative models for studying gene regulation. There is a big future for the study of pathways- particularly as genome deep sequencing technology matures and personalized medicine becomes a reality