TEACHER
Date:23 July
Time:12:35 - 12:50, 13:05 - 13:17 (GMT+8)
Global Program Head Clinical Development & Radiopharmaceuticals Platform Lead
Novartis
Radioligand therapy (RLT) represents a groundbreaking advancement in cancer treatment, offering a highly targeted approach that leverages the precision of nuclear medicine. RLT utilizes a ligand—a molecule specifically designed to bind to unique biomarkers on cancer cells—conjugated with a therapeutic radioisotope. This combination allows for the direct delivery of cytotoxic radiation to malignant cells while minimizing damage to surrounding healthy tissue, embodying the concept of “treating what you see” and enabling both diagnosis and therapy within a single platform.
The field of RLT has evolved significantly since its inception in the late 20th century, originating with radioimmunotherapy for hematological cancers. Recent decades have seen its application expand to solid tumors, such as neuroendocrine tumors and metastatic prostate cancer, where RLT has demonstrated meaningful improvements in disease control and patient quality of life, particularly for those who have exhausted conventional treatment options.
RLT’s uniqueness lies in its systemic yet highly selective action, which allows for repeated administration with tolerable side effects. The current landscape is marked by rapid growth, with over 320 clinical trials worldwide exploring novel tumor targets, new radioligands, and broader clinical indications. This momentum is driven by the promise of even greater precision and efficacy.
Looking to the future, innovations in radioisotope technology—especially the development of alpha-emitting isotopes like actinium-225 and lead-212—are poised to enhance the potency and specificity of RLT. Advances in ligand engineering, isotope production, and integrated care models are expected to further expand the therapeutic potential of RLT. As these innovations mature, radioligand therapy is set to become a cornerstone of personalized oncology, offering new hope for patients with challenging or treatment-resistant cancers.